Pause

Harvard NeuroDiscovery Center Biomarker Study

PIs:  Brad Hyman, MD, PhD

         Adrian Ivinson, PhD

         Clemens Scherzer, MD

Contact person:  Ana Trisini-Lipsanopoulos, Senior Project Manager

                            [email protected]

Contact method:  Please contact the site directly.

VRADB Application required for sample access?  No

Study Description:

HBS is a Harvard-wide, longitudinal, case-control study of 2,000+ individuals with memory and movement disorders as well as controls without neurologic disease. High-quality biosamples and high-resolution clinical phenotypes are tracked yearly. To minimize bias controls are enrolled from the source population, case and control samples are processed in parallel and quality-controlled. Hematological variables and processing steps are monitored.

For more information about HBS, please see our website:  http://neurodiscovery.harvard.edu/

Subjects:

Over 2,000 subjects have been enrolled and over 400 have completed three visits.  More than 80,000 biospecimens have been processed, quality-controlled, barcoded and stored ready for analysis.

DIAGNOSIS

Number  of Subjects with

Plasma, PRBC, Serum, RNA, miRNA

APOE

HLC

1st visit

2nd visit

3rd visit

4th visit

Alzheimer’s Disease (Probable/ Possible)

127

61

38

12

102

85

MCI (Amnestic/ Non-amnestic)

192

96

 

24

164

138

Impaired not MCI/ Other Dementias

240

144

 

33

186

146

Controls

667

398

 

61

508

388

Parkinson’s Disease

653

446

362

 

607

414

Neurodegenerative controls

101

36

35

 

64

32

TOTAL ALL SUBJECTS

1980

1181

435

130

1631

1203

NOTE: Total numbers are displayed as a general reference. Subject participation and QC checks are ongoing.

Material available:

Biospecimens collected include plasma, serum, microRNA, RNA, and whole blood, as well as DNA and immortalized cell lines, and ultimately, brain autopsy. Cerebrospinal fluid is longitudinally collected in a subset.

Other measurements available for this cohort: 

Core Clinical Data Elements

  • Demographics
  • Physical Assessment
  • Medical History
  • Exposures/Risk Factors
  • Family History of disorders
  • Social History
  • Medications
  • Mini Mental State Exam

 

Subset Clinical Data Elements

  • NeuroPsych Battery (for a subset only)
  • Movement Disorder Scales (for a subset only)